Archive for Publications

DEVELOPMENT AND VALIDATION OF A PROSTATE CANCER GENOMIC SIGNATURE THAT PREDICTS EARLY ADT TREATMENT RESPONSE FOLLOWING RADICAL PROSTATECTOMY

Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy. Clin Cancer Res.

SD-101 IN COMBINATION WITH PEMBROLIZUMAB IN ADVANCED MELANOMA: RESULTS OF A PHASE IB, MULTICENTER STUDY

SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study. 2018 Nov 1; [Epub ahead of print].

RADICAL PROSTATECTOMY, EXTERNAL BEAM RADIOTHERAPY, OR EXTERNAL BEAM RADIOTHERAPY WITH BRACHYTHERAPY BOOST AND DISEASE PROGRESSION AND MORTALITY IN PATIENTS WITH GLEASON SCORE 9-10 PROSTATE CANCER

Radical Prostatectomy, External Beam Radiotherapy, or External Beam Radiotherapy With Brachytherapy Boost and Disease Progression and Mortality in Patients With Gleason Score 9-10 Prostate Cancer. JAMA. 2018 Mar 6;319(9):896-905.

COMPOSITIONAL DIFFERENCES IN GASTROINTESTINAL MICROBIOTA IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN AXIS-TARGETED THERAPIES

Compositional Differences in Gastrointestinal Microbiota in Prostate Cancer Patients Treated with Androgen Axis-targeted Therapies.

DISTINCT TRANSCRIPTIONAL REPERTOIRE OF THE ANDROGEN RECEPTOR IN ETS FUSION-NEGATIVE PROSTATE CANCER

Distinct Transcriptional Repertoire of the Androgen Receptor in ETS Fusion-negative Prostate Cancer. Prostate Cancer Prostatic Dis. 2018

EFFECTS OF ALISERTIB, AN INVESTIGATIONAL AURORA A KINASE INHIBITOR ON THE QTC INTERVAL IN PATIENTS WITH ADVANCED MALIGNANCIES.

Zhou X, Nemunaitis J, Pant S, Bauer TM, Patel M, Sarantopoulos J, Lockhart AC, Goodman D, Huebner D, Mould DR, Venkatakrishnan K. Effects of Alisertib, an investigational Aurora A kinase inhibitor on the QTc interval in patients with advanced malignancies. Investigational New Drugs. 2017 Aug 18 [Epub ahead of print].

HARNESSING THE IMMUNE RESPONSE TO TARGET TUMORS

Manning L, Nemunaitis J. Harnessing the immune response to target tumors. Faculty of 1000. 2017 May 18;6:710. doi: 10.12688/f1000research.10795.1. eCollection 2017. Review.

A FIRST-IN-HUMAN, PHASE I, DOSE-ESCALATION STUDY OF TAK-117, A SELECTIVE PI3KΑ ISOFORM INHIBITOR, IN PATIENTS WITH ADVANCED SOLID MALIGNANCIES

Juric D, de Bono J, LoRusso P, Nemunaitis J, Heath EI, Kwak EL, Mercade TM, Geuna E, de Miguel-Luken MJ, Patel C, Kuida K, Sankoh S, Westin E, Zohren F, Shou Y, Tabernero J. A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies. Clinical Cancer Research. 2017 Sept 1;23(17):5015-5023.

SAFETY, TRAFFICKING AND ANTITUMOR ACTIVITY OF CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELLS SPECIFIC FOR TAG-72 IN PATIENTS WITH METASTATIC COLORECTAL CANCER

Hege KM, Bergsland EK, Fisher GA, Nemunaitis JJ, Warren RS, McArthur JG, Lin AA, Schlom J, June CH, Sherwin SA. Safety, Trafficking and Antitumor Activity of Chimeric Antigen Receptor (CAR)-T Cells Specific for TAG-72 in Patients with Metastatic Colorectal Cancer. Journal for Immunotherapy of Cancer. 2017 Mar 21; 5-22. eCollection 2017.

IMMUNE CHECKPOINT INHIBITOR ELICITED COMPLETE RESPONSE IN A HEAVILY PRETREATED PATIENT WITH METASTATIC ENDOMETRIAL CARCINOMA WITH A HIGH TUMOR MUTATION BURDEN (TMB)

Barve M, Adams N, Plato L, Dupler R, Anand R, Jones J, Brown M, Stephens PJ, Shiller SM, Senzer N, Nemunaitis J. Case Report: Immune Checkpoint Inhibitor Elicited Complete Response in a Heavily Pretreated Patient with Metastatic Endometrial Carcinoma with a High Tumor Mutation Burden (TMB). Molecular Medicine. 2017 Dec 6; 1(1):005.