Archive for White Papers

PERSONALIZED (AKA PRECISION) THERAPY-A SYSTEMS ANALYSIS OF CAPTURED MOLECULAR DATA

There are eight hallmark biological capabilities necessary for cancer development and persistence: (1) sustained proliferation, (2) evasion of growth suppressors, (3) death resistance …

TARGETING CANCER

The personalization of oncology treatments demands the alignment of patients’ molecular cancer growth mechanisms with the drugs which have been designed to target the cancer specific molecular signals.

HUMAN GENOME

The most common way people give up their power is by thinking they don’t have any.

MELANOMA

“Think about research for your advanced melanoma patient” – John Nemunaitis, MD

VACCINE INSIGHTS FROM ONGOING TRIALS

Mary Crowley presented at the American Society of Clinical Oncology 2013 Annual Conference on May 31, 2013.

CLINICAL UPDATE OF BIFUNCTIONAL (BI)-SHRNAI NANOPLEX TECHNOLOGY IN CANCER

Mary Crowley presented at the American Society of Gene and Cellular Therapy 2013 Annual Conference this May.

CLINICAL UPDATE OF BI-SHRNA FURIN/GMCSF DNA TRANSFECTED TUMOR VACCINE: FANG IN CANCER PATIENTS

Mary Crowley presented at the American Society of Gene and Cellular Therapy 2013 Annual Conference this May.

MOLECULAR MAPPING FOR PERSONALIZED CANCER THERAPEUTICS

Our understanding of the biomolecular basis of cancer has virtually exploded over the last 10 years. Developments in genetics, molecular biology, and molecular pharmacology promise to dramatically alter strategies of cancer treatment..

PHASE II CLINICAL TRIAL OF A GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR-ENCODING, SECOND-GENERATION ONCOLYTIC HERPESVIRUS

Treatment options for metastatic melanoma are limited. We conducted this phase II trial to assess the efficacy of JS1/34.5-/47-/granulocyte-macrophage colony-stimulating factor (GM-CSF) in stages IIIc and IV disease.

TRANSFORMING GROWTH FACTOR BETA

Belagenpumatucel is a non-viral gene based allogeneic tumor cell vaccine which demonstrates enhancement of tumor antigen recognition as a result of TGF-β2 inhibition.