A Multi-Regional, Open-Label, Dose Escalation and Dose Expansion Phase I Clinical Study to Investigate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of HF158K1 in Participants with HER-2 Positive or HER-2 Low Expression Advanced Solid Tumors
NCT #
NCT05861895
Condition(s)
Solid Tumor
Molecular Target(s)
HER2
Drug Classification(s)
Antibody Drug Conjugate, Immunotherapy, targeted
Agents(s)
HF158K1
Phase(s)
I
Mechanism of Action
HF158K1 is a HER2-targeting antibody liposome
Purpose
- How much of the study drug can be given with an acceptable level of side effects
- The effects of the study drug (good and bad)
- How much of the study drug is absorbed into the blood and how fast it is removed
- If research tests can be used in the future to predict who will benefit from HF158K1
- How the study drug is acting on your body
Location
MCD
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