A Phase 1/2a, Multi-Center, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Evidence of Antitumor Activity of JAB-2485 in Adult Patients With Advanced Solid Tumors
NCT #
NCT05490472
Condition(s)
Solid Tumor
Molecular Target(s)
Not Required
Drug Classification(s)
JAB-2485 is a small molecule Aurora A inhibitor
Agents(s)
JAB-2485
Phase(s)
I/II
Mechanism of Action
JAB-2485 is a small molecule Aurora A inhibitor. Inhibition of Aurora A activity at the cellular level, induces apoptosis and inhibits tumor growth.
Purpose
- How much of the study drug can be given with an acceptable level of side effects
- The effects of the study drug (good and bad)
- The effects of the study drug on tumor growth
- How much of the study drug is absorbed into the blood and how fast it is removed
- How the study drug is acting in your body
Location
MCD
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