A Phase 1 First-Time-in-Human, Open-Label Study of GSK4381562 Administered as Monotherapy and in Combination with Anticancer Agents in Participants with Selected Advanced Solid Tumors
Mechanism of Action
GSK4381562A is a PVRIG antibody to block this receptor thus preventing a signal that can inhibit the function of T cells in the immune system.
Purpose
- How much of the study agent 1 can be given alone, or in combination with Dostarlimab, or in combination with Dostarlimab and study agent 2 with an acceptable level of side effects
- The effects of the study agent 1 when given alone, or in combination with Dostarlimab, or in combination with Dostarlimab and study agent 2 (good and bad)
- How much of the study agent is absorbed into the blood and how fast it is removed
- If research tests can be used in the future to predict who will benefit from study agent 1 when given alone, or in combination with Dostarlimab, or in combination with Dostarlimab and study agent 2.
Location
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