A Phase 1, Multicenter, Open-Label, Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Intravenously Administered KT-253 in Adult Patients with High Grade Myeloid Malignancies and Acute Lymphocytic Leukemia, Lymphoma and Advanced Solid Tumors
NCT #
NCT05775406
Condition(s)
Lymphoma, Solid Tumor
Molecular Target(s)
MDM2
Drug Classification(s)
Molecular Targeted Therapy
Agents(s)
KT-253
Phase(s)
I
Mechanism of Action
KT-253 is an MDM2 degrader
Purpose
- How much of the study drug can be given with an acceptable level of side effects
- The effects of the study drug (good and bad)
- How much of the study drug is absorbed into the blood and how fast it is removed
- If research tests can be used in the future to predict who will benefit from KT-253
- How the study drug is acting on your body
Location
MCD
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