A Phase 1 Study of the Safety and Tolerability of COM902 in Subjects with Advanced Malignancies

MC #21-42

NCT #
NCT04354246
Condition(s)
Ovarian/ Peritoneal/ Fallopian Tube Cancer
Molecular Target(s)
PVRIG, TIGIT
Drug Classification(s)
Monoclonal Antibody
Agents(s)
TIGIT& PVRIG
Phase(s)
I

Mechanism of Action

COM701 is a monoclonal antibody against the poliovirus receptor-related immunoglobulin (PVRIG; PVR Related Immunoglobulin Domain Containing Protein; CD112R), a regulatory signal molecule expressed on cytotoxic T lymphocytes and NK cells. Blockade of PVRIG can prevent PVRIG-induced inhibition of T-lymphocyte and NK-cell activation. This sequence could enhance anti-tumor responses and immune-mediated tumor cell killing.

Purpose

  • How much of study agent 1 can be given alone and in combination with study agent 2 and Pembrolizumab with an acceptable level of side effects
  • The effects of the study agents (good and bad)
  • How much of the study agents are absorbed into the blood and how fast they are removed
  • If research tests can be used in the future to predict who will benefit from the study agent 1 and/or study agent 2

Location

MCD

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