A Phase 1 Study to Assess BDTX-1535, an Oral EGFR Inhibitor, in Patients with Glioblastoma or Non-Small Cell Lung Cancer
Mechanism of Action
BDTX-1535 selectively targets, irreversibly binds to, and inhibits the activity of various EGFR alterations and mutations. This prevents EGFR-mediated signaling in susceptible tumor cells. This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor cells.
Purpose
- How much of BDTX-1535 can be given with an acceptable level of side effects alone and in combination with temozolomide
- The effects of BDTX-1535 (good and bad) alone and in combination with temozolomide
- How much of BDTX-1535 is absorbed into the blood and how fast it is removed
Location
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