A Phase I/II, First-in-Human, Open-Label, Multiple Centre Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity and Preliminary Efficacy of LM-24C5 in Patients with Advanced Solid Tumors
NCT #
not yet registered
Condition(s)
Colorectal Cancer, Gastric/GEJ Cancer, Lung Cancer (NSCLC)
Molecular Target(s)
CD137, CEACAM5
Drug Classification(s)
Bispecific Antibodies, Molecular Targeted Therapy
Agents(s)
LM-24C5
Phase(s)
I/II
Mechanism of Action
LM-24C5 is a CEACAM5 x 4-1BB bispecific antibody
Purpose
- How much of the study agent can be given with an acceptable level of side effects
- The effects of the study agent (good and bad)
- How much of the study agent is absorbed into the blood and how fast it is removed
- How the study agent is acting on your body
Location
MCD
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