An Early Phase Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of PEEL-224 in Patients with Advanced Solid Tumors
NCT #
NCT05329103
Condition(s)
Solid Tumor
Molecular Target(s)
TOP1
Drug Classification(s)
Small Molecule (Targeted)
Agents(s)
PEEL-224
Phase(s)
I/II
Mechanism of Action
PEEL-223 is a small molecule topoisomerase 1 (TOP1) inhibitor, which may lead to inhibiting the repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations.
Purpose
- How much of the study drug can be given with an acceptable level of side effects
- The effects of the study drug (good and bad)
- How much of the study drug is absorbed into the blood and how fast it is removed
- If research tests can be used in the future to predict who will benefit from PEEL-224
Location
MCD
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